Neurotrophin and Neurotrophin Receptors in Human Fetal Kidney
نویسندگان
چکیده
منابع مشابه
Trk receptors: mediators of neurotrophin action.
The four mammalian neurotrophins - NGF, BDNF, NT-3 and NT-4 - each bind and activate one or more of the Trk family of receptor tyrosine kinases. Through these receptors, neurotrophins activate many intracellular signaling pathways, including those controlled by Ras, the Cdc42/Rac/RhoG protein family, MAPK, PI3K and PLC-gamma, thereby affecting both development and function of the nervous system...
متن کامل2 Signaling Through the Neurotrophin Receptors
3 The Neurotrophin Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 3.1 Structure of Trks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 3.2 Expression Profiles and Isoforms o...
متن کاملNeurotrophins and Neurotrophin Receptors in Proliferative Diabetic Retinopathy
Neurotrophins (NTs) are emerging as important mediators of angiogenesis and fibrosis. We investigated the expression of the NTs nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) and their receptors TrkA, TrkB, and TrkC in proliferative diabetic retinopathy (PDR). As a comparison, we examined the expression of NTs and their rece...
متن کاملNeurotrophins and Neurotrophin Receptors in Adult Brain Plasticity
265 Neurotrophic factors stimulate survival and growth of neurons during development and are involved in the regulation of neuronal survival, plasticity and regeneration in the adult nervous system. These growth factors offer an avenue to develop effective therapy for disorders associated with degeneration and neuron loss. Earlier studies showed that nerve growth factor (NGF) protects basal for...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 1996
ISSN: 0012-1606
DOI: 10.1006/dbio.1996.0268